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Proceedings SNO “LXI Congresso Nazionale SNO”
CAR T-cell toxicities
Organ system Toxicities
Costitutional Fever
Fatigue and malaise
Headache
Cardiovascular Sinus tachycardia
Hyotension
Decreased left ventricular ejection fraction
Arrhythmias
QT prolongation
Troponinemia
Respiratory Hypoxia
Dyspnea
Increased respiratori rate
Respiratory failure
Pleural effusions
Capillary leak syndrome
Renal Increased serum creatinine
Renal insufficiency
Hyponatremia
Hypokaliemia
Hypophosphatemia
Tumor lysis syndrome
Hepatic and Gastrointestinal Increases in liver transaminases: elevated ASpartate aminoTransferase (AST), ALanine
aminoTransferases (ALT), alkaline phosphatase, or direct bilirubin
Nausea, vomiting
Diarrhea
Hematologic Anemia
Thrombocytopenia
Neutropenia
B-cell aplasia
Hypogammaglobulinemia
Prolongation of partial Thromboplastin Time (PTT) or Prothombin Time (PT)
Decreased fibrinogen
Disseminated intravascular coagulation (DIC)
Hemophagocytic lymphohistiocytosis
Immunologic Risk of viral infections
Risk of bacterial infections
Risk of fungal infections
Musculoskeletal Cratine PhosphoKinase (CPK) elevation
Myalgias
Neurologic Delirium, encephalopaty
Somnolence, obtundation
Cognitive disturbance
Dysphasias
Tremors
Ataxia
Myoclonus
Focal motor and sensory defects
Seizures
Tabella 1.
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